教員情報
| 学部・学科 | 家政学部 健康栄養学科（Faculty of Home Economics Department of Health and Nutrition） |
|---|---|
| 職種 | 教授 （Professor） |
| 氏名（カナ） | カジタ カズオ |
| 氏名（漢字） | 梶田 和男 |
研究分野（field of study）
研究テーマ（Research theme）
研究実績一覧（Research Publications）
論文・資料作品等（Papers Material works）
| 表題 | 単・ 共著 |
刊行 | 概要（共著者名） | 関連授業科目 |
|---|---|---|---|---|
| Opposing Roles of Sphingosine 1-Phosphate Receptors 1 and 2 in Fat Deposition and Glucose Tolerance in Obese Male Mice. | 共著 Co-author |
Endocrinology 2023 Jan 9;164(3):bqad019. doi: 10.1210/endocr/bqad019. Asano M, Kajita K, Fuwa M, Kajita T, Mori I, Akahoshi N, Ishii I, Morita H |
肥満糖尿病マウスob/ob miceにS1P受容体1作動薬SEW-2871、S1P受容体2阻害薬JTE-013を投与した結果、同等に体重増加を抑制し、耐糖能障害を改善し、脂肪組織炎症を改善した。 Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that regulates fundamental cellular processes such as proliferation, migration, apoptosis, and differentiation through 5 cognate G protein-coupled receptors (S1P1-S1P5). We previously demonstrated that blockade of S1P2 signaling in S1P2-deficient mice attenuates high-fat diet-induced adipocyte hypertrophy and glucose intolerance and an S1P2-specific antagonist JTE-013 inhibits, whereas an S1P1/S1P3 dual antagonist (VPC23019) activates, adipogenic differentiation of preadipocytes. Based on those observations, this study examined whether an S1P1-specific agonist, SEW-2871, VPC23019, or their combination acts on obesity and glucose intolerance in leptin-deficient ob/ob mice. The oral administration of SEW-2871 or JTE-013 induced significant reductions in body/epididymal fat weight gains and epididymal/inguinal fat adipocyte sizes and improved glucose intolerance and adipocyte inflammation in ob/ob mice but not in their control C57BL/6J mice. Both SEW-2871 and JTE-013 decreased messenger RNA levels of tumor necrosis factor-α and CD11c, whereas they increased those of CD206 and adiponectin in the epididymal fats isolated from ob/ob mice with no changes in the levels of peroxisome proliferator activated receptor γ and its regulated genes. By contrast, VPC23019 did not cause any such alterations but counteracted with all those SEW-2871 actions in these mice. In conclusion, the S1P1 agonist SEW-2871 acted like the S1P2 antagonist JTE-013 to reduce body/epididymal fats and improve glucose tolerance in obese mice. Therefore, this study raises the possibility that endogenous S1P could promote obesity/type 2 diabetes through the S1P2, whereas exogenous S1P could act against them through the S1P1. |
